The "Duos" game.

[Mustrum_Ridcully]

Woody Harrelson & Kat Dennings in Defendor

[Mustrum_Ridcully]

No answer in nearly 24 hrs.?? 

I'll try to give it a restart:

Kat Dennings & Catherine Keener in "The 40 Year Old Virgin"

[Antares]

Catherine Keener & John Cusack in Being John Malkovich

[Dragonfire]

John Cusack and Amanda Peet in 2012

[Rogmeister]

Amanda Peet and Jack Black in Saving Silverman

[Achim]

Jack Black and Naomi Watts in King Kong

[kahless]

Naomi Watts & Armin Mueller-Stahl in "The International"

[Halo2]

Armin Mueller-Stahl & James Rebhorn in "The Game"

[Mustrum_Ridcully]

James Rebhorn & Al Pacino in Scent of a Woman

[kahless]

Al Pacino & Ellen Barkin in "Sea of Love"

[Rogmeister]

Ellen Barkin and JoBeth Williams in Switch

[Achim]

JoBeth Williams and Craig T. Nelson in Poultrygeist Poltergeist

[Mustrum_Ridcully]

Craig T. Nelson & Anne Heche in Wag the Dog

[dfmorgan]

Anne Heche and David Schwimmer in Six days, Seven Nights

Dave

[kahless]

David Schwimmer & Richard Jenkins in "Wolf"